Modern Technologies for Creating Synthetic Antibodies for Clinical application
نویسندگان
چکیده
The modular structure and versatility of antibodies enables one to modify natural immunoglobulins in different ways for various clinical applications. Rational design and molecular engineering make it possible to directionally modify the molecular size, affinity, specificity, and immunogenicity and effector functions of an antibody, as well as to combine them with other functional agents. This review focuses on up-to-date methods of antibody engineering for diagnosing and treating various diseases, particularly on new technologies meant to refine the effector functions of therapeutic antibodies.
منابع مشابه
Blood Group Typing: From Classical Strategies to the Application of Synthetic Antibodies Generated by Molecular Imprinting †
Blood transfusion requires a mandatory cross-match test to examine the compatibility between donor and recipient blood groups. Generally, in all cross-match tests, a specific chemical reaction of antibodies with erythrocyte antigens is carried out to monitor agglutination. Since the visual inspection is no longer useful for obtaining precise quantitative information, therefore there is a wide v...
متن کاملA Review on the Application of 3D Printing Technology in Radiotherapy for Breast Cancer
Breast cancer is considered as one of the main causes of cancer death in women. Early diagnosis and treatment, especially by modern technologies play major roles in management of breast cancer. Radiation therapy is known as one of the main treatment options for breast cancer. Nowadays, 3D printing technology is also used to rapidly construct objects with high quality. Many studies have shown th...
متن کاملبهبود کارایی با استفاده از فناوری‌های روز در شرکت ملی نفت ایران
This paper tries to survey the effective factors in creating an appropriate environment for improving advanced technologies in Iranian National Oil Company and it offers some solutions for applying these technologies. In the beginning, the paper mentions the growing demand for oil more than its global supply in the years to come as well as the need to increase the oil reservoirs and recycling c...
متن کاملThe measurement technologies of thyrotropin receptor antibodies from the past to the present
Thyroid Stimulating Hormone Receptor (TSH-R) autoantibodies are the main cause of Graveschr('39') disease and its external thyroid manifestations such as ophtalmopathy and dermatopathy. These antibodies are functionally different and are commonly called TSH receptor antibodies (TRAbs). In fact, TRAbs are a set of autoantibodies including TSHR-stimulating antibodies (TSAbs), TSHR- blocking antib...
متن کاملTissue Engineered Scaffolds in Regenerative Medicine
Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2009